1H-Pyrrolo[3,2-b]pyridine, 3-iodo-
3-Iodo-1H-pyrrolo[3,2-b]pyridine
CAS: 1083181-26-3
Molecular Formula: C7H5IN2
1H-Pyrrolo[3,2-b]pyridine, 3-iodo- - Names and Identifiers
| Name | 3-Iodo-1H-pyrrolo[3,2-b]pyridine |
| Synonyms | 3-Iodo-4-azaindole 3-Iodo-1H-pyrrolo[3,2-b]pyridine 3-iodo-1H-pyrrolo[3,2-b]pyridine 1H-Pyrrolo[3,2-b]pyridine, 3-iodo- |
| CAS | 1083181-26-3 |
1H-Pyrrolo[3,2-b]pyridine, 3-iodo- - Physico-chemical Properties
| Molecular Formula | C7H5IN2 |
| Molar Mass | 244.03 |
| Density | 2.082 |
| Boling Point | 360.7±22.0 °C(Predicted) |
| pKa | 13.16±0.40(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
1H-Pyrrolo[3,2-b]pyridine, 3-iodo- - Reference Information
| introduction | 3-iodine-1H-pyrrolo [3,2-B] pyridine is an organic intermediate, which can be obtained by iodination of 1H-pyrrolo [3,2-b] pyridine. |
| use | 3-iodine-1H-pyrrolo [3,2-B] pyridine is a pyridine derivative that can be used to prepare plasma kallikrein inhibitors. |
| preparation method | NIS(6.3g,27.9mmol,1.1 equivalent) is added to the solution of 1H-pyrrolo [3,2-b] pyridine (3.0g,25.4mmol,1.0 equivalent) in THF(20mL). Precipitation occurs after a few minutes. Continue stirring at room temperature overnight. The sediment was collected by filtration and washed with a small amount of THF. The resulting solid was vacuum-dried to give 3-iodine-1H-pyrrolo [3,2-B] pyridine (5.8g,93.5%). |
Last Update：2024-04-09 21:04:16
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